Generic Name: factor XIII (FAK tor 13 (thirteen))
Brand Names: Corifact
What is factor XIII?
Factor XIII is used to prevent bleeding episodes in people with a hereditary bleeding disorder caused by a deficiency of Factor XIII.
Factor XIII will not treat a bleeding episode that has already begun.
Factor XIII may also be used for purposes not listed in this medication guide.
What is the most important information I should know about factor XIII?
You should not use this medication if you are allergic to factor XIII or to any medicine made with human plasma.
Before using factor XIII, tell your doctor if you have liver disease.
You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Call your doctor at once if you have new or worsening bleeding episodes, sudden numbness or weakness, chest pain, coughing up blood, problems with vision or speech, or pain, swelling, warmth, or redness in one or both legs.
What should I discuss with my healthcare provider before taking factor XIII?
You should not use this medication if you are allergic to factor XIII or to any medicine made with human plasma.
To make sure you can safely take factor XIII, tell your doctor if you have liver disease.
FDA pregnancy category C. It is not known whether factor XIII will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether factor XIII passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Factor XIII is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.
How should I take factor XIII?
Factor XIII is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Factor XIII is usually given once every 4 weeks. Follow your doctor's dosing instructions very carefully.
Factor XIII is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.
Allow the mixture to reach room temperature before giving the injection. Do not heat the medicine before using.
Factor XIII should look clear or slightly yellow in color. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Do not mix factor XIII with other injectable medications in the same IV line.
Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
To be sure this medication is helping your condition, your blood may need to be tested often. Visit your doctor regularly.
Store unmixed factor XIII in the refrigerator, do not freeze. Keep the medicine in its original container. Unopened vials of factor XIII may also be stored at room temperature for up to 6 months, away from moisture, heat, and light. Do not refrigerate an unopened vial that has been stored at room temperature. After mixing factor XIII with a diluent, store at room temperature and use within 4 hours. Do not refrigerate or freeze.
Throw away any unused factor XIII after the expiration date on the label has passed.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of factor XIII.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking factor XIII?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Factor XIII side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
new or worsening bleeding episodes;
unusual bruising;
sudden numbness or weakness, especially on one side of the body;
sudden severe headache, confusion, problems with vision, speech, or balance;
chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
pain, swelling, warmth, or redness in one or both legs.
Less serious side effects may include:
fever, chills, flu symptoms;
stomach pain, vomiting, diarrhea,
headache;
joint pain;
mild rash or itching; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect factor XIII?
There may be other drugs that can interact with factor XIII. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
More Corifact resources
- Corifact Side Effects (in more detail)
- Corifact Use in Pregnancy & Breastfeeding
- Corifact Support Group
- 0 Reviews for Corifact - Add your own review/rating
- Corifact Prescribing Information (FDA)
- Corifact Advanced Consumer (Micromedex) - Includes Dosage Information
- Corifact MedFacts Consumer Leaflet (Wolters Kluwer)
- Corifact Consumer Overview
Compare Corifact with other medications
- Factor XIII Deficiency
Where can I get more information?
- Your pharmacist can provide more information about factor XIII.
See also: Corifact side effects (in more detail)
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